https://optics.eee.nottingham.ac.uk/w/api.php?action=feedcontributions&user=Qimei+Zhang&feedformat=atomApplied Optics Wiki - User contributions [en]2024-03-29T05:16:50ZUser contributionsMediaWiki 1.27.1https://optics.eee.nottingham.ac.uk/w/index.php?title=Qimei_Zhang&diff=3208Qimei Zhang2017-01-17T12:09:42Z<p>Qimei Zhang: /* Biography */</p>
<hr />
<div>==Contact==<br />
<br />
'''Location:''' <br />
: 1003 Tower Building, University Park, University of Nottingham, <br />
: Nottingham, NG7 2RD<br />
<br />
'''Tel:''' <br />
: 0115 9515112<br />
<br />
'''Email:''' <br />
: ezaqz2@exmail.nottingham.ac.uk<br />
<br />
'''Research Topics:'''<br />
: Ultrasound Modulated Optical Tomography<br />
: Contrast agents<br />
: Microbubbles, liposomes<br />
: Fluorescence and bioluminescence imaging<br />
: Fiber optical sensors<br />
: Wearable device<br />
: Signal processing, Modelling<br />
<br />
==Biography==<br />
<br />
Qimei Zhang received her B.S. degree in Electronics and Information Engineering from Beihang University, Beijing, China, in 2011. Since October 2012, she has been working toward the PhD degree in Electrical and Electronics engineering at the University of Nottingham, Nottingham, U. K. Qimei Zhang received her PhD degree in July 2016. From October 2015 to Marth 2016, Qimei Zhang is working as a research associate on biomedical optics simulation. Since June 2016, Qimei Zhang is working as a research associate on photonics textiles. Her research interests include ultrasound modulated optical imaging, contrast agent, biomedical optics, biomedical imaging, optical fiber sensors, and wearable device.<br />
<br />
==Publications==<br />
<br />
<bibtex><br />
<br />
@ARTICLE{ZhangQimei2016, <br />
author={Q. Zhang and S. P. Morgan and P. O'Shea and M. L. Mather}, <br />
journal={PLoS One}, <br />
title={Ultrasound Induced Fluorescence of Nanoscale Liposome Contrast Agents}, <br />
year={2016}, <br />
volume={11}, <br />
number={7}, <br />
pages={e0159742}, <br />
month={Jul},}<br />
</bibtex><br />
<br />
<bibtex><br />
@ARTICLE{ZhangQimei2015, <br />
author={Q. Zhang and M. L. Mather and S. P. Morgan}, <br />
journal={IEEE Transactions on Biomedical Engineering}, <br />
title={Numerical Investigation of the Mechanisms of Ultrasound-Modulated Bioluminescence Tomography}, <br />
year={2015}, <br />
volume={62}, <br />
number={9}, <br />
pages={2135-2143}, <br />
month={Sept},}<br />
<br />
</bibtex></div>Qimei Zhanghttps://optics.eee.nottingham.ac.uk/w/index.php?title=Qimei_Zhang&diff=3207Qimei Zhang2017-01-17T12:04:56Z<p>Qimei Zhang: /* Contact */</p>
<hr />
<div>==Contact==<br />
<br />
'''Location:''' <br />
: 1003 Tower Building, University Park, University of Nottingham, <br />
: Nottingham, NG7 2RD<br />
<br />
'''Tel:''' <br />
: 0115 9515112<br />
<br />
'''Email:''' <br />
: ezaqz2@exmail.nottingham.ac.uk<br />
<br />
'''Research Topics:'''<br />
: Ultrasound Modulated Optical Tomography<br />
: Contrast agents<br />
: Microbubbles, liposomes<br />
: Fluorescence and bioluminescence imaging<br />
: Fiber optical sensors<br />
: Wearable device<br />
: Signal processing, Modelling<br />
<br />
==Biography==<br />
<br />
Qimei Zhang received her B.S. degree in Electronics and Information Engineering from Beihang University, Beijing, China, in 2011. Since 2012, she has been working toward the PhD degree in Electrical and Electronics engineering at the University of Nottingham, Nottingham, U. K. Her research interests include ultrasound modulated optical imaging, contrast agent, and biomedical imaging.<br />
<br />
==Publications==<br />
<br />
<bibtex><br />
<br />
@ARTICLE{ZhangQimei2016, <br />
author={Q. Zhang and S. P. Morgan and P. O'Shea and M. L. Mather}, <br />
journal={PLoS One}, <br />
title={Ultrasound Induced Fluorescence of Nanoscale Liposome Contrast Agents}, <br />
year={2016}, <br />
volume={11}, <br />
number={7}, <br />
pages={e0159742}, <br />
month={Jul},}<br />
</bibtex><br />
<br />
<bibtex><br />
@ARTICLE{ZhangQimei2015, <br />
author={Q. Zhang and M. L. Mather and S. P. Morgan}, <br />
journal={IEEE Transactions on Biomedical Engineering}, <br />
title={Numerical Investigation of the Mechanisms of Ultrasound-Modulated Bioluminescence Tomography}, <br />
year={2015}, <br />
volume={62}, <br />
number={9}, <br />
pages={2135-2143}, <br />
month={Sept},}<br />
<br />
</bibtex></div>Qimei Zhanghttps://optics.eee.nottingham.ac.uk/w/index.php?title=Qimei_Zhang&diff=3206Qimei Zhang2017-01-17T12:04:09Z<p>Qimei Zhang: /* Publications */</p>
<hr />
<div>==Contact==<br />
<br />
'''Location:''' <br />
: 1003 Tower Building, University Park, University of Nottingham, <br />
: Nottingham, NG7 2RD<br />
<br />
'''Tel:''' <br />
: 0115 9515112<br />
<br />
'''Email:''' <br />
: ezaqz2@exmail.nottingham.ac.uk<br />
<br />
'''Research Topics:'''<br />
: Ultrasound Modulated Optical Tomography<br />
: Contrast agents<br />
: Microbubbles, liposomes<br />
: Fluorescence and bioluminescence imaging<br />
: Fiber optical sensors<br />
: Wearable device<br />
: Signal processing<br />
<br />
==Biography==<br />
<br />
Qimei Zhang received her B.S. degree in Electronics and Information Engineering from Beihang University, Beijing, China, in 2011. Since 2012, she has been working toward the PhD degree in Electrical and Electronics engineering at the University of Nottingham, Nottingham, U. K. Her research interests include ultrasound modulated optical imaging, contrast agent, and biomedical imaging.<br />
<br />
==Publications==<br />
<br />
<bibtex><br />
<br />
@ARTICLE{ZhangQimei2016, <br />
author={Q. Zhang and S. P. Morgan and P. O'Shea and M. L. Mather}, <br />
journal={PLoS One}, <br />
title={Ultrasound Induced Fluorescence of Nanoscale Liposome Contrast Agents}, <br />
year={2016}, <br />
volume={11}, <br />
number={7}, <br />
pages={e0159742}, <br />
month={Jul},}<br />
</bibtex><br />
<br />
<bibtex><br />
@ARTICLE{ZhangQimei2015, <br />
author={Q. Zhang and M. L. Mather and S. P. Morgan}, <br />
journal={IEEE Transactions on Biomedical Engineering}, <br />
title={Numerical Investigation of the Mechanisms of Ultrasound-Modulated Bioluminescence Tomography}, <br />
year={2015}, <br />
volume={62}, <br />
number={9}, <br />
pages={2135-2143}, <br />
month={Sept},}<br />
<br />
</bibtex></div>Qimei Zhanghttps://optics.eee.nottingham.ac.uk/w/index.php?title=Qimei_Zhang&diff=3205Qimei Zhang2017-01-17T12:03:37Z<p>Qimei Zhang: /* Contact */</p>
<hr />
<div>==Contact==<br />
<br />
'''Location:''' <br />
: 1003 Tower Building, University Park, University of Nottingham, <br />
: Nottingham, NG7 2RD<br />
<br />
'''Tel:''' <br />
: 0115 9515112<br />
<br />
'''Email:''' <br />
: ezaqz2@exmail.nottingham.ac.uk<br />
<br />
'''Research Topics:'''<br />
: Ultrasound Modulated Optical Tomography<br />
: Contrast agents<br />
: Microbubbles, liposomes<br />
: Fluorescence and bioluminescence imaging<br />
: Fiber optical sensors<br />
: Wearable device<br />
: Signal processing<br />
<br />
==Biography==<br />
<br />
Qimei Zhang received her B.S. degree in Electronics and Information Engineering from Beihang University, Beijing, China, in 2011. Since 2012, she has been working toward the PhD degree in Electrical and Electronics engineering at the University of Nottingham, Nottingham, U. K. Her research interests include ultrasound modulated optical imaging, contrast agent, and biomedical imaging.<br />
<br />
==Publications==<br />
<br />
<bibtex><br />
<br />
@ARTICLE{ZhangQimei2016, <br />
author={Q. Zhang and S. P. Morgan and P. O'Shea and M. L. Mather}, <br />
journal={PLoS One}, <br />
title={Ultrasound Induced Fluorescence of Nanoscale Liposome Contrast Agents}, <br />
year={2016}, <br />
volume={11}, <br />
number={7}, <br />
pages={e0159742}, <br />
month={Jul},}<br />
<br />
@ARTICLE{ZhangQimei2015, <br />
author={Q. Zhang and M. L. Mather and S. P. Morgan}, <br />
journal={IEEE Transactions on Biomedical Engineering}, <br />
title={Numerical Investigation of the Mechanisms of Ultrasound-Modulated Bioluminescence Tomography}, <br />
year={2015}, <br />
volume={62}, <br />
number={9}, <br />
pages={2135-2143}, <br />
month={Sept},}<br />
<br />
</bibtex></div>Qimei Zhanghttps://optics.eee.nottingham.ac.uk/w/index.php?title=Qimei_Zhang&diff=3204Qimei Zhang2017-01-17T12:00:10Z<p>Qimei Zhang: /* Publications */</p>
<hr />
<div>==Contact==<br />
<br />
'''Location:''' <br />
: 1003 Tower Building, University Park, University of Nottingham, <br />
: Nottingham, NG7 2RD<br />
<br />
'''Tel:''' <br />
: 0115 9515112<br />
<br />
'''Email:''' <br />
: eexqz10@nottingham.ac.uk<br />
<br />
'''Research Topics:'''<br />
: Ultrasound Modulated Optical Tomography<br />
: Contrast agents<br />
<br />
==Biography==<br />
<br />
Qimei Zhang received her B.S. degree in Electronics and Information Engineering from Beihang University, Beijing, China, in 2011. Since 2012, she has been working toward the PhD degree in Electrical and Electronics engineering at the University of Nottingham, Nottingham, U. K. Her research interests include ultrasound modulated optical imaging, contrast agent, and biomedical imaging.<br />
<br />
==Publications==<br />
<br />
<bibtex><br />
<br />
@ARTICLE{ZhangQimei2016, <br />
author={Q. Zhang and S. P. Morgan and P. O'Shea and M. L. Mather}, <br />
journal={PLoS One}, <br />
title={Ultrasound Induced Fluorescence of Nanoscale Liposome Contrast Agents}, <br />
year={2016}, <br />
volume={11}, <br />
number={7}, <br />
pages={e0159742}, <br />
month={Jul},}<br />
<br />
@ARTICLE{ZhangQimei2015, <br />
author={Q. Zhang and M. L. Mather and S. P. Morgan}, <br />
journal={IEEE Transactions on Biomedical Engineering}, <br />
title={Numerical Investigation of the Mechanisms of Ultrasound-Modulated Bioluminescence Tomography}, <br />
year={2015}, <br />
volume={62}, <br />
number={9}, <br />
pages={2135-2143}, <br />
month={Sept},}<br />
<br />
</bibtex></div>Qimei Zhanghttps://optics.eee.nottingham.ac.uk/w/index.php?title=Ultrasound_modulated_optical_tomography_using_contrast_agents&diff=2715Ultrasound modulated optical tomography using contrast agents2016-04-27T20:56:43Z<p>Qimei Zhang: /* Projects */</p>
<hr />
<div> <br />
==Introduction==<br />
<br />
Macroscopic fluorescence imaging and bioluminescence imaging are important molecular imaging methods for deep tissue interrogations. However, the imaging depth and resolution are limited by strong tissue scattering and absorption. The hybrid technique Ultrasound modulated luminescence tomography (USMLT) has been investigated in recent years aiming to provide images with ultrasound resolution (< 1 mm) in deep tissue (>10 mm). In this technique, a focused ultrasound is used to modulate the source particle region (e.g. fluorophores) or the optical properties of a scattering medium and the modulated signal is detected. By scanning the US beam, images can be obtained with a resolution decided by the ultrasound focal zone. However, this technique has a limitation that the modulation depth (ratio of the modulated light with unmodulated light) is extremely low leading to a low SNR for the system. The aim of this project is thus to increase the modulation depth (or the US On-to-Off ratio) of USMLT.<br />
<br />
==Projects==<br />
<br />
1) The mechanisms of USMLT are investigated. This is achieved through incorporate the effects of ultrasound modulation to an open source tool NIRFAST for simulation of diffusely propagating light. The modulated fluorescent signal is successfully calculated through the finite element method. The effects of four factors (reduced optical scattering coefficient, optical absorption coefficient, refractive index, and luciferase concentration) on the depth of light modulation are compared.<br />
<br />
2) The fluorophore-labelled microbubbles are investigated as a contrast agent. Fluorophore-labeled MBs can be tuned to be self-quenched at optimized concentration of fluorophore per MBs. With application of US, fluorophore-labeled microbubbles oscillate and thus result in the intermolecular spacing alteration. Such intermolecular oscillation could lead to a higher modulation of fluorescence signal of fluorophore-labeled MBs due to the fluorescence recovery of the self-quenched fluorophore.<br />
<br />
[[Image:Qimei_Zhang_schameticFMB.png|400px]]<br />
<br />
3) Pyrene labelled liposomes are investigated as another contrast agent. Pyrene has a well-known concentration dependant excimer formation characteristics. In this project pyrene are labelled in the lipid bilayer of nanoscale liposomes and the excimer fluorescence intensity upon application of ultrasound is monitored.<br />
<br />
4) Donor-acceptor labelled liposomes are also investigated as a contrast agent based on fluorescence resonance energy transfer (FRET). This contrast agent works at near-infrared wavelength range which is better for deep tissue imaging.<br />
<br />
==Publications==<br />
<bibtex><br />
<br />
@ARTICLE{ZhangQimei2015, <br />
author={Q. Zhang and M. L. Mather and S. P. Morgan}, <br />
journal={IEEE Transactions on Biomedical Engineering}, <br />
title={Numerical Investigation of the Mechanisms of Ultrasound-Modulated Bioluminescence Tomography}, <br />
year={2015}, <br />
volume={62}, <br />
number={9}, <br />
pages={2135-2143}, <br />
month={Sept},}<br />
<br />
</bibtex></div>Qimei Zhanghttps://optics.eee.nottingham.ac.uk/w/index.php?title=File:Qimei_Zhang_PyPCUS7800ms.png&diff=2714File:Qimei Zhang PyPCUS7800ms.png2016-04-27T20:53:20Z<p>Qimei Zhang: uploaded a new version of &quot;File:Qimei Zhang PyPCUS7800ms.png&quot;</p>
<hr />
<div></div>Qimei Zhanghttps://optics.eee.nottingham.ac.uk/w/index.php?title=File:Qimei_Zhang_PyPCUS7800ms.png&diff=2713File:Qimei Zhang PyPCUS7800ms.png2016-04-27T20:52:34Z<p>Qimei Zhang: uploaded a new version of &quot;File:Qimei Zhang PyPCUS7800ms.png&quot;</p>
<hr />
<div></div>Qimei Zhanghttps://optics.eee.nottingham.ac.uk/w/index.php?title=File:Qimei_Zhang_PyPCUS7800ms.png&diff=2712File:Qimei Zhang PyPCUS7800ms.png2016-04-27T20:51:21Z<p>Qimei Zhang: </p>
<hr />
<div></div>Qimei Zhanghttps://optics.eee.nottingham.ac.uk/w/index.php?title=Ultrasound_modulated_optical_tomography_using_contrast_agents&diff=2710Ultrasound modulated optical tomography using contrast agents2016-04-27T00:02:32Z<p>Qimei Zhang: </p>
<hr />
<div> <br />
==Introduction==<br />
<br />
Macroscopic fluorescence imaging and bioluminescence imaging are important molecular imaging methods for deep tissue interrogations. However, the imaging depth and resolution are limited by strong tissue scattering and absorption. The hybrid technique Ultrasound modulated luminescence tomography (USMLT) has been investigated in recent years aiming to provide images with ultrasound resolution (< 1 mm) in deep tissue (>10 mm). In this technique, a focused ultrasound is used to modulate the source particle region (e.g. fluorophores) or the optical properties of a scattering medium and the modulated signal is detected. By scanning the US beam, images can be obtained with a resolution decided by the ultrasound focal zone. However, this technique has a limitation that the modulation depth (ratio of the modulated light with unmodulated light) is extremely low leading to a low SNR for the system. The aim of this project is thus to increase the modulation depth (or the US On-to-Off ratio) of USMLT.<br />
<br />
==Projects==<br />
<br />
1) The mechanisms of USMLT are investigated. This is achieved through incorporate the effects of ultrasound modulation to an open source tool NIRFAST for simulation of diffusely propagating light. The modulated fluorescent signal is successfully calculated through the finite element method. The effects of four factors (reduced optical scattering coefficient, optical absorption coefficient, refractive index, and luciferase concentration) on the depth of light modulation are compared.<br />
<br />
2) The fluorophore-labelled microbubbles are investigated as a contrast agent. Fluorophore-labeled MBs can be tuned to be self-quenched at optimized concentration of fluorophore per MBs. With application of US, fluorophore-labeled microbubbles oscillate and thus result in the intermolecular spacing alteration. Such intermolecular oscillation could lead to a higher modulation of fluorescence signal of fluorophore-labeled MBs due to the fluorescence recovery of the self-quenched fluorophore.<br />
<br />
[[Image:Qimei_Zhang_schameticFMB.png|400px]]<br />
<br />
3) Pyrene labelled liposomes are investigated as another contrast agent. Pyrene has a well-known concentration dependant excimer formation characteristics. In this project pyrene are labelled in the lipid bilayer of nanoscale liposomes and the excimer fluorescence intensity upon application of ultrasound is monitored.<br />
<br />
4) Donor-acceptor labelled liposomes are also investigated as a contrast agent based on fluorescence resonance energy transfer (FRET). This contrast agent works at near-infrared wavelength range which is better for deep tissue imaging.<br />
<br />
==Publications==<br />
<bibtex><br />
<br />
@ARTICLE{ZhangQimei2015, <br />
author={Q. Zhang and M. L. Mather and S. P. Morgan}, <br />
journal={IEEE Transactions on Biomedical Engineering}, <br />
title={Numerical Investigation of the Mechanisms of Ultrasound-Modulated Bioluminescence Tomography}, <br />
year={2015}, <br />
volume={62}, <br />
number={9}, <br />
pages={2135-2143}, <br />
month={Sept},}<br />
<br />
</bibtex></div>Qimei Zhanghttps://optics.eee.nottingham.ac.uk/w/index.php?title=Ultrasound_modulated_optical_tomography_using_contrast_agents&diff=2709Ultrasound modulated optical tomography using contrast agents2016-04-27T00:01:30Z<p>Qimei Zhang: /* Ultrasound mediated luminescence tomography using contrast agents */</p>
<hr />
<div> <br />
==Introduction:==<br />
<br />
Macroscopic fluorescence imaging and bioluminescence imaging are important molecular imaging methods for deep tissue interrogations. However, the imaging depth and resolution are limited by strong tissue scattering and absorption. The hybrid technique Ultrasound modulated luminescence tomography (USMLT) has been investigated in recent years aiming to provide images with ultrasound resolution (< 1 mm) in deep tissue (>10 mm). In this technique, a focused ultrasound is used to modulate the source particle region (e.g. fluorophores) or the optical properties of a scattering medium and the modulated signal is detected. By scanning the US beam, images can be obtained with a resolution decided by the ultrasound focal zone. However, this technique has a limitation that the modulation depth (ratio of the modulated light with unmodulated light) is extremely low leading to a low SNR for the system. The aim of this project is thus to increase the modulation depth (or the US On-to-Off ratio) of USMLT.<br />
<br />
==Projects:==<br />
<br />
1) The mechanisms of USMLT are investigated. This is achieved through incorporate the effects of ultrasound modulation to an open source tool NIRFAST for simulation of diffusely propagating light. The modulated fluorescent signal is successfully calculated through the finite element method. The effects of four factors (reduced optical scattering coefficient, optical absorption coefficient, refractive index, and luciferase concentration) on the depth of light modulation are compared.<br />
[[Image:Qimei_Zhang_USMBLTSimulation.pdf]]<br />
<br />
2) The fluorophore-labelled microbubbles are investigated as a contrast agent. Fluorophore-labeled MBs can be tuned to be self-quenched at optimized concentration of fluorophore per MBs. With application of US, fluorophore-labeled microbubbles oscillate and thus result in the intermolecular spacing alteration. Such intermolecular oscillation could lead to a higher modulation of fluorescence signal of fluorophore-labeled MBs due to the fluorescence recovery of the self-quenched fluorophore.<br />
<br />
[[Image:Qimei_Zhang_schameticFMB.png|400px]]<br />
<br />
[[Image:Qimei_Zhang_10pulse0dot75um100kPa.pdf]]<br />
<br />
3) Pyrene labelled liposomes are investigated as another contrast agent. Pyrene has a well-known concentration dependant excimer formation characteristics. In this project pyrene are labelled in the lipid bilayer of nanoscale liposomes and the excimer fluorescence intensity upon application of ultrasound is monitored.<br />
<br />
4) Donor-acceptor labelled liposomes are also investigated as a contrast agent based on fluorescence resonance energy transfer (FRET). This contrast agent works at near-infrared wavelength range which is better for deep tissue imaging.<br />
<br />
Publications:<br />
<bibtex><br />
<br />
@ARTICLE{ZhangQimei2015, <br />
author={Q. Zhang and M. L. Mather and S. P. Morgan}, <br />
journal={IEEE Transactions on Biomedical Engineering}, <br />
title={Numerical Investigation of the Mechanisms of Ultrasound-Modulated Bioluminescence Tomography}, <br />
year={2015}, <br />
volume={62}, <br />
number={9}, <br />
pages={2135-2143}, <br />
month={Sept},}<br />
<br />
</bibtex></div>Qimei Zhanghttps://optics.eee.nottingham.ac.uk/w/index.php?title=Qimei_Zhang&diff=2708Qimei Zhang2016-04-27T00:00:46Z<p>Qimei Zhang: </p>
<hr />
<div>==Contact==<br />
<br />
'''Location:''' <br />
: 1003 Tower Building, University Park, University of Nottingham, <br />
: Nottingham, NG7 2RD<br />
<br />
'''Tel:''' <br />
: 0115 9515112<br />
<br />
'''Email:''' <br />
: eexqz10@nottingham.ac.uk<br />
<br />
'''Research Topics:'''<br />
: Ultrasound Modulated Optical Tomography<br />
: Contrast agents<br />
<br />
==Biography==<br />
<br />
Qimei Zhang received her B.S. degree in Electronics and Information Engineering from Beihang University, Beijing, China, in 2011. Since 2012, she has been working toward the PhD degree in Electrical and Electronics engineering at the University of Nottingham, Nottingham, U. K. Her research interests include ultrasound modulated optical imaging, contrast agent, and biomedical imaging.<br />
<br />
==Publications==<br />
<br />
<bibtex><br />
<br />
@ARTICLE{ZhangQimei2015, <br />
author={Q. Zhang and M. L. Mather and S. P. Morgan}, <br />
journal={IEEE Transactions on Biomedical Engineering}, <br />
title={Numerical Investigation of the Mechanisms of Ultrasound-Modulated Bioluminescence Tomography}, <br />
year={2015}, <br />
volume={62}, <br />
number={9}, <br />
pages={2135-2143}, <br />
month={Sept},}<br />
<br />
</bibtex></div>Qimei Zhanghttps://optics.eee.nottingham.ac.uk/w/index.php?title=Qimei_Zhang&diff=2707Qimei Zhang2016-04-26T23:59:50Z<p>Qimei Zhang: </p>
<hr />
<div>==Contact:==<br />
<br />
'''Location:''' <br />
: 1003 Tower Building, University Park, University of Nottingham, <br />
: Nottingham, NG7 2RD<br />
<br />
'''Tel:''' <br />
: 0115 9515112<br />
<br />
'''Email:''' <br />
: eexqz10@nottingham.ac.uk<br />
<br />
'''Research Topics:'''<br />
: Ultrasound Modulated Optical Tomography<br />
: Contrast agents<br />
<br />
==Biography:==<br />
<br />
Qimei Zhang received her B.S. degree in Electronics and Information Engineering from Beihang University, Beijing, China, in 2011. Since 2012, she has been working toward the PhD degree in Electrical and Electronics engineering at the University of Nottingham, Nottingham, U. K. Her research interests include ultrasound modulated optical imaging, contrast agent, and biomedical imaging.<br />
<br />
==Publications==<br />
<br />
<bibtex><br />
<br />
@ARTICLE{ZhangQimei2015, <br />
author={Q. Zhang and M. L. Mather and S. P. Morgan}, <br />
journal={IEEE Transactions on Biomedical Engineering}, <br />
title={Numerical Investigation of the Mechanisms of Ultrasound-Modulated Bioluminescence Tomography}, <br />
year={2015}, <br />
volume={62}, <br />
number={9}, <br />
pages={2135-2143}, <br />
month={Sept},}<br />
<br />
</bibtex></div>Qimei Zhanghttps://optics.eee.nottingham.ac.uk/w/index.php?title=Qimei_Zhang&diff=2706Qimei Zhang2016-04-26T23:58:18Z<p>Qimei Zhang: </p>
<hr />
<div>==Contact:==<br />
<br />
'''Location:''' 1003 Tower Building, University Park, University of Nottingham, Nottingham, NG7 2RD<br />
<br />
'''Tel:''' 0115 9515112<br />
<br />
'''Email:''' eexqz10@nottingham.ac.uk<br />
<br />
'''Research Topics:'''<br />
Ultrasound Modulated Optical Tomography<br />
: Contrast agents<br />
<br />
==Biography:==<br />
<br />
Qimei Zhang received her B.S. degree in Electronics and Information Engineering from Beihang University, Beijing, China, in 2011. Since 2012, she has been working toward the PhD degree in Electrical and Electronics engineering at the University of Nottingham, Nottingham, U. K. Her research interests include ultrasound modulated optical imaging, contrast agent, and biomedical imaging.<br />
<br />
==Publications==<br />
<br />
<bibtex><br />
<br />
@ARTICLE{ZhangQimei2015, <br />
author={Q. Zhang and M. L. Mather and S. P. Morgan}, <br />
journal={IEEE Transactions on Biomedical Engineering}, <br />
title={Numerical Investigation of the Mechanisms of Ultrasound-Modulated Bioluminescence Tomography}, <br />
year={2015}, <br />
volume={62}, <br />
number={9}, <br />
pages={2135-2143}, <br />
month={Sept},}<br />
<br />
</bibtex></div>Qimei Zhanghttps://optics.eee.nottingham.ac.uk/w/index.php?title=Qimei_Zhang&diff=2705Qimei Zhang2016-04-26T23:52:00Z<p>Qimei Zhang: </p>
<hr />
<div>==Contact:==<br />
<br />
'''Location:''' 1003 Tower Building, University Park, University of Nottingham, Nottingham, NG7 2RD<br />
<br />
'''Email:''' eexqz10@nottingham.ac.uk<br />
<br />
'''Research Topics:'''<br />
Ultrasound Modulated Optical Tomography<br />
<br />
==Publications==<br />
<br />
<bibtex><br />
<br />
@ARTICLE{ZhangQimei2015, <br />
author={Q. Zhang and M. L. Mather and S. P. Morgan}, <br />
journal={IEEE Transactions on Biomedical Engineering}, <br />
title={Numerical Investigation of the Mechanisms of Ultrasound-Modulated Bioluminescence Tomography}, <br />
year={2015}, <br />
volume={62}, <br />
number={9}, <br />
pages={2135-2143}, <br />
month={Sept},}<br />
<br />
</bibtex></div>Qimei Zhanghttps://optics.eee.nottingham.ac.uk/w/index.php?title=Qimei_Zhang&diff=2704Qimei Zhang2016-04-26T23:47:32Z<p>Qimei Zhang: Created page with "__NOTOC__ ==Qimei Zhang== {|class="wikitable" align="right" |- | |- |} '''Location:''' Tower 1003 '''Email'''''(< at > nottingham.ac.uk)''''':''' eexqz10 '''Research Topics:..."</p>
<hr />
<div>__NOTOC__<br />
==Qimei Zhang==<br />
<br />
{|class="wikitable" align="right"<br />
|-<br />
|<br />
|-<br />
|}<br />
<br />
<br />
'''Location:''' Tower 1003<br />
<br />
'''Email'''''(< at > nottingham.ac.uk)''''':''' eexqz10<br />
<br />
'''Research Topics:'''<br />
Ultrasound Modulated Optical Tomography<br />
Contrast agents<br />
<br />
==Publications==<br />
<br />
<bibtex><br />
<br />
@ARTICLE{ZhangQimei2015, <br />
author={Q. Zhang and M. L. Mather and S. P. Morgan}, <br />
journal={IEEE Transactions on Biomedical Engineering}, <br />
title={Numerical Investigation of the Mechanisms of Ultrasound-Modulated Bioluminescence Tomography}, <br />
year={2015}, <br />
volume={62}, <br />
number={9}, <br />
pages={2135-2143}, <br />
month={Sept},}<br />
<br />
</bibtex></div>Qimei Zhanghttps://optics.eee.nottingham.ac.uk/w/index.php?title=Ultrasound_modulated_optical_tomography_using_contrast_agents&diff=2703Ultrasound modulated optical tomography using contrast agents2016-04-26T23:39:20Z<p>Qimei Zhang: </p>
<hr />
<div> <br />
==Ultrasound mediated luminescence tomography using contrast agents==<br />
<br />
==Introduction:==<br />
<br />
Macroscopic fluorescence imaging and bioluminescence imaging are important molecular imaging methods for deep tissue interrogations. However, the imaging depth and resolution are limited by strong tissue scattering and absorption. The hybrid technique Ultrasound modulated luminescence tomography (USMLT) has been investigated in recent years aiming to provide images with ultrasound resolution (< 1 mm) in deep tissue (>10 mm). In this technique, a focused ultrasound is used to modulate the source particle region (e.g. fluorophores) or the optical properties of a scattering medium and the modulated signal is detected. By scanning the US beam, images can be obtained with a resolution decided by the ultrasound focal zone. However, this technique has a limitation that the modulation depth (ratio of the modulated light with unmodulated light) is extremely low leading to a low SNR for the system. The aim of this project is thus to increase the modulation depth (or the US On-to-Off ratio) of USMLT.<br />
<br />
==Projects:==<br />
<br />
1) The mechanisms of USMLT are investigated. This is achieved through incorporate the effects of ultrasound modulation to an open source tool NIRFAST for simulation of diffusely propagating light. The modulated fluorescent signal is successfully calculated through the finite element method. The effects of four factors (reduced optical scattering coefficient, optical absorption coefficient, refractive index, and luciferase concentration) on the depth of light modulation are compared.<br />
[[Image:Qimei_Zhang_USMBLTSimulation.pdf]]<br />
<br />
2) The fluorophore-labelled microbubbles are investigated as a contrast agent. Fluorophore-labeled MBs can be tuned to be self-quenched at optimized concentration of fluorophore per MBs. With application of US, fluorophore-labeled microbubbles oscillate and thus result in the intermolecular spacing alteration. Such intermolecular oscillation could lead to a higher modulation of fluorescence signal of fluorophore-labeled MBs due to the fluorescence recovery of the self-quenched fluorophore.<br />
<br />
[[Image:Qimei_Zhang_schameticFMB.png|400px]]<br />
<br />
[[Image:Qimei_Zhang_10pulse0dot75um100kPa.pdf]]<br />
<br />
3) Pyrene labelled liposomes are investigated as another contrast agent. Pyrene has a well-known concentration dependant excimer formation characteristics. In this project pyrene are labelled in the lipid bilayer of nanoscale liposomes and the excimer fluorescence intensity upon application of ultrasound is monitored.<br />
<br />
4) Donor-acceptor labelled liposomes are also investigated as a contrast agent based on fluorescence resonance energy transfer (FRET). This contrast agent works at near-infrared wavelength range which is better for deep tissue imaging.<br />
<br />
Publications:<br />
<bibtex><br />
<br />
@ARTICLE{ZhangQimei2015, <br />
author={Q. Zhang and M. L. Mather and S. P. Morgan}, <br />
journal={IEEE Transactions on Biomedical Engineering}, <br />
title={Numerical Investigation of the Mechanisms of Ultrasound-Modulated Bioluminescence Tomography}, <br />
year={2015}, <br />
volume={62}, <br />
number={9}, <br />
pages={2135-2143}, <br />
month={Sept},}<br />
<br />
</bibtex></div>Qimei Zhanghttps://optics.eee.nottingham.ac.uk/w/index.php?title=Ultrasound_modulated_optical_tomography_using_contrast_agents&diff=2702Ultrasound modulated optical tomography using contrast agents2016-04-26T23:21:47Z<p>Qimei Zhang: /* Projects: */</p>
<hr />
<div> <br />
==Ultrasound mediated luminescence tomography using contrast agents==<br />
<br />
==Introduction:==<br />
<br />
Macroscopic fluorescence imaging and bioluminescence imaging are important molecular imaging methods for deep tissue interrogations. However, the imaging depth and resolution are limited by strong tissue scattering and absorption. The hybrid technique Ultrasound modulated luminescence tomography (USMLT) has been investigated in recent years aiming to provide images with ultrasound resolution (< 1 mm) in deep tissue (>10 mm). In this technique, a focused ultrasound is used to modulate the source particle region (e.g. fluorophores) or the optical properties of a scattering medium and the modulated signal is detected. By scanning the US beam, images can be obtained with a resolution decided by the ultrasound focal zone. However, this technique has a limitation that the modulation depth (ratio of the modulated light with unmodulated light) is extremely low leading to a low SNR for the system. The aim of this project is thus to increase the modulation depth (or the US On-to-Off ratio) of USMLT.<br />
<br />
==Projects:==<br />
<br />
1) The mechanisms of USMLT are investigated. This is achieved through incorporate the effects of ultrasound modulation to an open source tool NIRFAST for simulation of diffusely propagating light. The modulated fluorescent signal is successfully calculated through the finite element method. The effects of four factors (reduced optical scattering coefficient, optical absorption coefficient, refractive index, and luciferase concentration) on the depth of light modulation are compared.<br />
[[Image:Qimei_Zhang_USMBLTSimulation.pdf]]<br />
<br />
2) The fluorophore-labelled microbubbles are investigated as a contrast agent. Fluorophore-labeled MBs can be tuned to be self-quenched at optimized concentration of fluorophore per MBs. With application of US, fluorophore-labeled microbubbles oscillate and thus result in the intermolecular spacing alteration. Such intermolecular oscillation could lead to a higher modulation of fluorescence signal of fluorophore-labeled MBs due to the fluorescence recovery of the self-quenched fluorophore.<br />
<br />
[[Image:Qimei_Zhang_schameticFMB]]<br />
<br />
[[Image:Qimei_Zhang_10pulse0dot75um100kPa.pdf]]<br />
<br />
3) Pyrene labelled liposomes are investigated as another contrast agent. Pyrene has a well-known concentration dependant excimer formation characteristics. In this project pyrene are labelled in the lipid bilayer of nanoscale liposomes and the excimer fluorescence intensity upon application of ultrasound is monitored.<br />
<br />
4) Donor-acceptor labelled liposomes are also investigated as a contrast agent based on fluorescence resonance energy transfer (FRET). This contrast agent works at near-infrared wavelength range which is better for deep tissue imaging.<br />
<br />
Publications:</div>Qimei Zhanghttps://optics.eee.nottingham.ac.uk/w/index.php?title=Ultrasound_modulated_optical_tomography_using_contrast_agents&diff=2701Ultrasound modulated optical tomography using contrast agents2016-04-26T23:20:39Z<p>Qimei Zhang: /* Projects: */</p>
<hr />
<div> <br />
==Ultrasound mediated luminescence tomography using contrast agents==<br />
<br />
==Introduction:==<br />
<br />
Macroscopic fluorescence imaging and bioluminescence imaging are important molecular imaging methods for deep tissue interrogations. However, the imaging depth and resolution are limited by strong tissue scattering and absorption. The hybrid technique Ultrasound modulated luminescence tomography (USMLT) has been investigated in recent years aiming to provide images with ultrasound resolution (< 1 mm) in deep tissue (>10 mm). In this technique, a focused ultrasound is used to modulate the source particle region (e.g. fluorophores) or the optical properties of a scattering medium and the modulated signal is detected. By scanning the US beam, images can be obtained with a resolution decided by the ultrasound focal zone. However, this technique has a limitation that the modulation depth (ratio of the modulated light with unmodulated light) is extremely low leading to a low SNR for the system. The aim of this project is thus to increase the modulation depth (or the US On-to-Off ratio) of USMLT.<br />
<br />
==Projects:==<br />
<br />
1) The mechanisms of USMLT are investigated. This is achieved through incorporate the effects of ultrasound modulation to an open source tool NIRFAST for simulation of diffusely propagating light. The modulated fluorescent signal is successfully calculated through the finite element method. The effects of four factors (reduced optical scattering coefficient, optical absorption coefficient, refractive index, and luciferase concentration) on the depth of light modulation are compared.<br />
[[File:Qimei_Zhang_USMBLTSimulation.pdf]]<br />
<br />
2) The fluorophore-labelled microbubbles are investigated as a contrast agent. Fluorophore-labeled MBs can be tuned to be self-quenched at optimized concentration of fluorophore per MBs. With application of US, fluorophore-labeled microbubbles oscillate and thus result in the intermolecular spacing alteration. Such intermolecular oscillation could lead to a higher modulation of fluorescence signal of fluorophore-labeled MBs due to the fluorescence recovery of the self-quenched fluorophore.<br />
<br />
[[File:Qimei_Zhang_schameticFMB]]<br />
<br />
[[File:Qimei_Zhang_10pulse0dot75um100kPa.pdf]]<br />
<br />
3) Pyrene labelled liposomes are investigated as another contrast agent. Pyrene has a well-known concentration dependant excimer formation characteristics. In this project pyrene are labelled in the lipid bilayer of nanoscale liposomes and the excimer fluorescence intensity upon application of ultrasound is monitored.<br />
<br />
4) Donor-acceptor labelled liposomes are also investigated as a contrast agent based on fluorescence resonance energy transfer (FRET). This contrast agent works at near-infrared wavelength range which is better for deep tissue imaging.<br />
<br />
Publications:</div>Qimei Zhanghttps://optics.eee.nottingham.ac.uk/w/index.php?title=File:Qimei_Zhang_10pulse0dot75um100kPa.pdf&diff=2700File:Qimei Zhang 10pulse0dot75um100kPa.pdf2016-04-26T23:19:24Z<p>Qimei Zhang: </p>
<hr />
<div></div>Qimei Zhanghttps://optics.eee.nottingham.ac.uk/w/index.php?title=File:Qimei_Zhang_schameticFMB.png&diff=2699File:Qimei Zhang schameticFMB.png2016-04-26T23:18:49Z<p>Qimei Zhang: </p>
<hr />
<div></div>Qimei Zhanghttps://optics.eee.nottingham.ac.uk/w/index.php?title=File:Qimei_Zhang_USMBLTSimulation.pdf&diff=2698File:Qimei Zhang USMBLTSimulation.pdf2016-04-26T23:18:01Z<p>Qimei Zhang: </p>
<hr />
<div></div>Qimei Zhanghttps://optics.eee.nottingham.ac.uk/w/index.php?title=Ultrasound_modulated_optical_tomography_using_contrast_agents&diff=2697Ultrasound modulated optical tomography using contrast agents2016-04-26T23:01:43Z<p>Qimei Zhang: Created page with " ==Ultrasound mediated luminescence tomography using contrast agents== ==Introduction:== Macroscopic fluorescence imaging and bioluminescence imaging are important molec..."</p>
<hr />
<div> <br />
==Ultrasound mediated luminescence tomography using contrast agents==<br />
<br />
==Introduction:==<br />
<br />
Macroscopic fluorescence imaging and bioluminescence imaging are important molecular imaging methods for deep tissue interrogations. However, the imaging depth and resolution are limited by strong tissue scattering and absorption. The hybrid technique Ultrasound modulated luminescence tomography (USMLT) has been investigated in recent years aiming to provide images with ultrasound resolution (< 1 mm) in deep tissue (>10 mm). In this technique, a focused ultrasound is used to modulate the source particle region (e.g. fluorophores) or the optical properties of a scattering medium and the modulated signal is detected. By scanning the US beam, images can be obtained with a resolution decided by the ultrasound focal zone. However, this technique has a limitation that the modulation depth (ratio of the modulated light with unmodulated light) is extremely low leading to a low SNR for the system. The aim of this project is thus to increase the modulation depth (or the US On-to-Off ratio) of USMLT.<br />
<br />
==Projects:==<br />
<br />
1) The mechanisms of USMLT are investigated. This is achieved through incorporate the effects of ultrasound modulation to an open source tool NIRFAST for simulation of diffusely propagating light. The modulated fluorescent signal is successfully calculated through the finite element method. The effects of four factors (reduced optical scattering coefficient, optical absorption coefficient, refractive index, and luciferase concentration) on the depth of light modulation are compared.<br />
<br />
(one picture)<br />
<br />
2) The fluorophore-labelled microbubbles are investigated as a contrast agent. Fluorophore-labeled MBs can be tuned to be self-quenched at optimized concentration of fluorophore per MBs. With application of US, fluorophore-labeled microbubbles oscillate and thus result in the intermolecular spacing alteration. Such intermolecular oscillation could lead to a higher modulation of fluorescence signal of fluorophore-labeled MBs due to the fluorescence recovery of the self-quenched fluorophore.<br />
<br />
(two pictures)<br />
<br />
3) Pyrene labelled liposomes are investigated as another contrast agent. Pyrene has a well-known concentration dependant excimer formation characteristics. In this project pyrene are labelled in the lipid bilayer of nanoscale liposomes and the excimer fluorescence intensity upon application of ultrasound is monitored.<br />
<br />
(one picture)<br />
<br />
<br />
<br />
4) Donor-acceptor labelled liposomes are also investigated as a contrast agent based on fluorescence resonance energy transfer (FRET). This contrast agent works at near-infrared wavelength range which is better for deep tissue imaging.<br />
<br />
Publications:</div>Qimei Zhang