https://optics.eee.nottingham.ac.uk/w/index.php?title=Endoscopic,_Spectroscopic_Imaging_of_the_Middle_Ear&feed=atom&action=history
Endoscopic, Spectroscopic Imaging of the Middle Ear - Revision history
2024-03-29T07:40:16Z
Revision history for this page on the wiki
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https://optics.eee.nottingham.ac.uk/w/index.php?title=Endoscopic,_Spectroscopic_Imaging_of_the_Middle_Ear&diff=2396&oldid=prev
David Jung: /* Related Publications */
2015-09-14T08:18:46Z
<p><span dir="auto"><span class="autocomment">Related Publications</span></span></p>
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<td colspan='2' style="background-color: white; color:black; text-align: center;">← Older revision</td>
<td colspan='2' style="background-color: white; color:black; text-align: center;">Revision as of 08:18, 14 September 2015</td>
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<tr><td class='diff-marker'> </td><td style="background-color: #f9f9f9; color: #333333; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #e6e6e6; vertical-align: top; white-space: pre-wrap;"></td><td class='diff-marker'> </td><td style="background-color: #f9f9f9; color: #333333; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #e6e6e6; vertical-align: top; white-space: pre-wrap;"></td></tr>
<tr><td class='diff-marker'> </td><td style="background-color: #f9f9f9; color: #333333; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #e6e6e6; vertical-align: top; white-space: pre-wrap;"><div>==Related Publications==</div></td><td class='diff-marker'> </td><td style="background-color: #f9f9f9; color: #333333; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #e6e6e6; vertical-align: top; white-space: pre-wrap;"><div>==Related Publications==</div></td></tr>
<tr><td class='diff-marker'>−</td><td style="color:black; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div>* <del class="diffchange diffchange-inline">David </del>S. <del class="diffchange diffchange-inline">Jung</del>; <del class="diffchange diffchange-inline">John </del>P. <del class="diffchange diffchange-inline">Birchall</del>; <del class="diffchange diffchange-inline">John </del>A. <del class="diffchange diffchange-inline">Crowe</del>; <del class="diffchange diffchange-inline">Chung </del>W. <del class="diffchange diffchange-inline">See</del>; <del class="diffchange diffchange-inline">Michael </del>G. <del class="diffchange diffchange-inline">Somekh</del>, "'''Monte Carlo Photon Simulation of an Anti-Confocal System to Monitor Middle Ear Inflammation'''," in Optics in the Life Sciences, OSA Technical Digest (CD) (Optical Society of America, 2015), paper JT3A.41.</div></td><td class='diff-marker'>+</td><td style="color:black; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div>* <ins class="diffchange diffchange-inline">Jung, D.</ins>S.; <ins class="diffchange diffchange-inline">Birchall, J.</ins>P.; <ins class="diffchange diffchange-inline">Crowe, J.</ins>A.; <ins class="diffchange diffchange-inline">See, C.</ins>W.; <ins class="diffchange diffchange-inline">and Somekh, M.</ins>G., "'''Monte Carlo Photon Simulation of an Anti-Confocal System to Monitor Middle Ear Inflammation'''," in Optics in the Life Sciences, OSA Technical Digest (CD) (Optical Society of America, 2015), paper JT3A.41.</div></td></tr>
<tr><td class='diff-marker'>−</td><td style="color:black; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div>* <del class="diffchange diffchange-inline">David </del>S. <del class="diffchange diffchange-inline">Jung</del>, <del class="diffchange diffchange-inline">John </del>A. <del class="diffchange diffchange-inline">Crowe</del>, <del class="diffchange diffchange-inline">John </del>P. <del class="diffchange diffchange-inline">Birchall</del>, <del class="diffchange diffchange-inline">Michael </del>G. <del class="diffchange diffchange-inline">Somekh</del>, <del class="diffchange diffchange-inline">and Chung </del>W. <del class="diffchange diffchange-inline">See</del>, "'''Anti-confocal versus confocal assessment of the middle ear simulated by Monte Carlo methods'''," Biomed. Opt. Express 6, 3820-3825 (2015).</div></td><td class='diff-marker'>+</td><td style="color:black; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div>* <ins class="diffchange diffchange-inline">Jung, D.</ins>S.<ins class="diffchange diffchange-inline">; Crowe</ins>, <ins class="diffchange diffchange-inline">J.</ins>A.<ins class="diffchange diffchange-inline">; Birchall</ins>, <ins class="diffchange diffchange-inline">J.</ins>P.<ins class="diffchange diffchange-inline">; Somekh</ins>, <ins class="diffchange diffchange-inline">M.</ins>G.<ins class="diffchange diffchange-inline">; and See</ins>, <ins class="diffchange diffchange-inline">C.</ins>W., "'''Anti-confocal versus confocal assessment of the middle ear simulated by Monte Carlo methods'''," Biomed. Opt. Express 6, 3820-3825 (2015).</div></td></tr>
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David Jung
https://optics.eee.nottingham.ac.uk/w/index.php?title=Endoscopic,_Spectroscopic_Imaging_of_the_Middle_Ear&diff=2394&oldid=prev
David Jung at 08:15, 14 September 2015
2015-09-14T08:15:25Z
<p></p>
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<td colspan='2' style="background-color: white; color:black; text-align: center;">← Older revision</td>
<td colspan='2' style="background-color: white; color:black; text-align: center;">Revision as of 08:15, 14 September 2015</td>
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<tr><td class='diff-marker'> </td><td style="background-color: #f9f9f9; color: #333333; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #e6e6e6; vertical-align: top; white-space: pre-wrap;"><div>==Related Publications==</div></td><td class='diff-marker'> </td><td style="background-color: #f9f9f9; color: #333333; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #e6e6e6; vertical-align: top; white-space: pre-wrap;"><div>==Related Publications==</div></td></tr>
<tr><td class='diff-marker'>−</td><td style="color:black; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div>* <del class="diffchange diffchange-inline">Jung, D.</del>S.; <del class="diffchange diffchange-inline">Birchall, J.</del>P.; <del class="diffchange diffchange-inline">Crowe, J.</del>A.; <del class="diffchange diffchange-inline">See, C.</del>W.; <del class="diffchange diffchange-inline">Somekh, M.</del>G., "'''Monte Carlo Photon Simulation of an Anti-Confocal System to Monitor Middle Ear Inflammation'''," in Optics in the Life Sciences, OSA Technical Digest (CD) (Optical Society of America, 2015), paper JT3A.41.</div></td><td class='diff-marker'>+</td><td style="color:black; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div>* <ins class="diffchange diffchange-inline">David </ins>S. <ins class="diffchange diffchange-inline">Jung</ins>; <ins class="diffchange diffchange-inline">John </ins>P. <ins class="diffchange diffchange-inline">Birchall</ins>; <ins class="diffchange diffchange-inline">John </ins>A. <ins class="diffchange diffchange-inline">Crowe</ins>; <ins class="diffchange diffchange-inline">Chung </ins>W. <ins class="diffchange diffchange-inline">See</ins>; <ins class="diffchange diffchange-inline">Michael </ins>G. <ins class="diffchange diffchange-inline">Somekh</ins>, "'''Monte Carlo Photon Simulation of an Anti-Confocal System to Monitor Middle Ear Inflammation'''," in Optics in the Life Sciences, OSA Technical Digest (CD) (Optical Society of America, 2015), paper JT3A.41<ins class="diffchange diffchange-inline">.</ins></div></td></tr>
<tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="color:black; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins class="diffchange diffchange-inline">* David S. Jung, John A. Crowe, John P. Birchall, Michael G. Somekh, and Chung W. See, "'''Anti-confocal versus confocal assessment of the middle ear simulated by Monte Carlo methods'''," Biomed. Opt. Express 6, 3820-3825 (2015)</ins>.</div></td></tr>
</table>
David Jung
https://optics.eee.nottingham.ac.uk/w/index.php?title=Endoscopic,_Spectroscopic_Imaging_of_the_Middle_Ear&diff=2261&oldid=prev
David Jung at 08:43, 6 May 2015
2015-05-06T08:43:52Z
<p></p>
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<td colspan='2' style="background-color: white; color:black; text-align: center;">← Older revision</td>
<td colspan='2' style="background-color: white; color:black; text-align: center;">Revision as of 08:43, 6 May 2015</td>
</tr><tr><td colspan="2" class="diff-lineno" id="mw-diff-left-l28" >Line 28:</td>
<td colspan="2" class="diff-lineno">Line 28:</td></tr>
<tr><td class='diff-marker'> </td><td style="background-color: #f9f9f9; color: #333333; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #e6e6e6; vertical-align: top; white-space: pre-wrap;"><div>===Tissue Phantoms===</div></td><td class='diff-marker'> </td><td style="background-color: #f9f9f9; color: #333333; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #e6e6e6; vertical-align: top; white-space: pre-wrap;"><div>===Tissue Phantoms===</div></td></tr>
<tr><td class='diff-marker'> </td><td style="background-color: #f9f9f9; color: #333333; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #e6e6e6; vertical-align: top; white-space: pre-wrap;"><div>Animal eardrums have been characterised and investigated in order to find tissue models for the human eardrum. Further, epoxy resin based tissue phantoms have been produced to model healthy and inflamed mucosa. These phantoms will provide a middle ear model for testing of the optical system.</div></td><td class='diff-marker'> </td><td style="background-color: #f9f9f9; color: #333333; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #e6e6e6; vertical-align: top; white-space: pre-wrap;"><div>Animal eardrums have been characterised and investigated in order to find tissue models for the human eardrum. Further, epoxy resin based tissue phantoms have been produced to model healthy and inflamed mucosa. These phantoms will provide a middle ear model for testing of the optical system.</div></td></tr>
<tr><td class='diff-marker'>−</td><td style="color:black; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div><del style="font-weight: bold; text-decoration: none;"></del></div></td><td colspan="2"> </td></tr>
<tr><td class='diff-marker'> </td><td style="background-color: #f9f9f9; color: #333333; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #e6e6e6; vertical-align: top; white-space: pre-wrap;"><div>===Optical System===</div></td><td class='diff-marker'> </td><td style="background-color: #f9f9f9; color: #333333; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #e6e6e6; vertical-align: top; white-space: pre-wrap;"><div>===Optical System===</div></td></tr>
<tr><td class='diff-marker'> </td><td style="background-color: #f9f9f9; color: #333333; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #e6e6e6; vertical-align: top; white-space: pre-wrap;"><div>The optical system is set up as bench top system. A CCD sensor is used as confocal detector to allow easy variations of the filtering element of the (anti)-confocal system in software during post processing of the measurements.</div></td><td class='diff-marker'> </td><td style="background-color: #f9f9f9; color: #333333; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #e6e6e6; vertical-align: top; white-space: pre-wrap;"><div>The optical system is set up as bench top system. A CCD sensor is used as confocal detector to allow easy variations of the filtering element of the (anti)-confocal system in software during post processing of the measurements.</div></td></tr>
<tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="color:black; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;"></ins></div></td></tr>
<tr><td class='diff-marker'> </td><td style="background-color: #f9f9f9; color: #333333; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #e6e6e6; vertical-align: top; white-space: pre-wrap;"><div>==Future Work==</div></td><td class='diff-marker'> </td><td style="background-color: #f9f9f9; color: #333333; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #e6e6e6; vertical-align: top; white-space: pre-wrap;"><div>==Future Work==</div></td></tr>
<tr><td class='diff-marker'> </td><td style="background-color: #f9f9f9; color: #333333; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #e6e6e6; vertical-align: top; white-space: pre-wrap;"><div>Next steps are to experimentally characterise the optical system and proof the concept using the tissue simulating phantoms. When shown to be working the system can be minimised and adopted for clinical use and tested on human subjects.</div></td><td class='diff-marker'> </td><td style="background-color: #f9f9f9; color: #333333; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #e6e6e6; vertical-align: top; white-space: pre-wrap;"><div>Next steps are to experimentally characterise the optical system and proof the concept using the tissue simulating phantoms. When shown to be working the system can be minimised and adopted for clinical use and tested on human subjects.</div></td></tr>
<tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="color:black; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;"></ins></div></td></tr>
<tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="color:black; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">==Related Publications==</ins></div></td></tr>
<tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="color:black; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">* Jung, D.S.; Birchall, J.P.; Crowe, J.A.; See, C.W.; Somekh, M.G., "'''Monte Carlo Photon Simulation of an Anti-Confocal System to Monitor Middle Ear Inflammation'''," in Optics in the Life Sciences, OSA Technical Digest (CD) (Optical Society of America, 2015), paper JT3A.41.</ins></div></td></tr>
</table>
David Jung
https://optics.eee.nottingham.ac.uk/w/index.php?title=Endoscopic,_Spectroscopic_Imaging_of_the_Middle_Ear&diff=2260&oldid=prev
David Jung: /* Tissue Phantoms */
2015-05-06T08:42:14Z
<p><span dir="auto"><span class="autocomment">Tissue Phantoms</span></span></p>
<table class="diff diff-contentalign-left" data-mw="interface">
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<td colspan='2' style="background-color: white; color:black; text-align: center;">← Older revision</td>
<td colspan='2' style="background-color: white; color:black; text-align: center;">Revision as of 08:42, 6 May 2015</td>
</tr><tr><td colspan="2" class="diff-lineno" id="mw-diff-left-l27" >Line 27:</td>
<td colspan="2" class="diff-lineno">Line 27:</td></tr>
<tr><td class='diff-marker'> </td><td style="background-color: #f9f9f9; color: #333333; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #e6e6e6; vertical-align: top; white-space: pre-wrap;"><div>Imaging of the middle ear using the anti-confocal system has been simulated using Monte-Carlo methods and compared to a conventional confocal system. The simulation shows an improved performance of the anti-confocal system considering signal strength and signal-to-background ratio.</div></td><td class='diff-marker'> </td><td style="background-color: #f9f9f9; color: #333333; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #e6e6e6; vertical-align: top; white-space: pre-wrap;"><div>Imaging of the middle ear using the anti-confocal system has been simulated using Monte-Carlo methods and compared to a conventional confocal system. The simulation shows an improved performance of the anti-confocal system considering signal strength and signal-to-background ratio.</div></td></tr>
<tr><td class='diff-marker'> </td><td style="background-color: #f9f9f9; color: #333333; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #e6e6e6; vertical-align: top; white-space: pre-wrap;"><div>===Tissue Phantoms===</div></td><td class='diff-marker'> </td><td style="background-color: #f9f9f9; color: #333333; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #e6e6e6; vertical-align: top; white-space: pre-wrap;"><div>===Tissue Phantoms===</div></td></tr>
<tr><td class='diff-marker'>−</td><td style="color:black; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div>Animal eardrums have been characterised and investigated in order to find tissue models for the human eardrum. Further, epoxy resin based tissue phantoms have been produced to model healthy and inflamed mucosa.</div></td><td class='diff-marker'>+</td><td style="color:black; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div>Animal eardrums have been characterised and investigated in order to find tissue models for the human eardrum. Further, epoxy resin based tissue phantoms have been produced to model healthy and inflamed mucosa. <ins class="diffchange diffchange-inline">These phantoms will provide a middle ear model for testing of the optical system.</ins></div></td></tr>
<tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="color:black; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div> </div></td></tr>
<tr><td class='diff-marker'> </td><td style="background-color: #f9f9f9; color: #333333; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #e6e6e6; vertical-align: top; white-space: pre-wrap;"><div>===Optical System===</div></td><td class='diff-marker'> </td><td style="background-color: #f9f9f9; color: #333333; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #e6e6e6; vertical-align: top; white-space: pre-wrap;"><div>===Optical System===</div></td></tr>
<tr><td class='diff-marker'> </td><td style="background-color: #f9f9f9; color: #333333; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #e6e6e6; vertical-align: top; white-space: pre-wrap;"><div>The optical system is set up as bench top system. A CCD sensor is used as confocal detector to allow easy variations of the filtering element of the (anti)-confocal system in software during post processing of the measurements.</div></td><td class='diff-marker'> </td><td style="background-color: #f9f9f9; color: #333333; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #e6e6e6; vertical-align: top; white-space: pre-wrap;"><div>The optical system is set up as bench top system. A CCD sensor is used as confocal detector to allow easy variations of the filtering element of the (anti)-confocal system in software during post processing of the measurements.</div></td></tr>
<tr><td class='diff-marker'> </td><td style="background-color: #f9f9f9; color: #333333; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #e6e6e6; vertical-align: top; white-space: pre-wrap;"><div>==Future Work==</div></td><td class='diff-marker'> </td><td style="background-color: #f9f9f9; color: #333333; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #e6e6e6; vertical-align: top; white-space: pre-wrap;"><div>==Future Work==</div></td></tr>
<tr><td class='diff-marker'> </td><td style="background-color: #f9f9f9; color: #333333; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #e6e6e6; vertical-align: top; white-space: pre-wrap;"><div>Next steps are to experimentally characterise the optical system and proof the concept using the tissue simulating phantoms. When shown to be working the system can be minimised and adopted for clinical use and tested on human subjects.</div></td><td class='diff-marker'> </td><td style="background-color: #f9f9f9; color: #333333; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #e6e6e6; vertical-align: top; white-space: pre-wrap;"><div>Next steps are to experimentally characterise the optical system and proof the concept using the tissue simulating phantoms. When shown to be working the system can be minimised and adopted for clinical use and tested on human subjects.</div></td></tr>
</table>
David Jung
https://optics.eee.nottingham.ac.uk/w/index.php?title=Endoscopic,_Spectroscopic_Imaging_of_the_Middle_Ear&diff=2259&oldid=prev
David Jung at 08:40, 6 May 2015
2015-05-06T08:40:12Z
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<td colspan='2' style="background-color: white; color:black; text-align: center;">← Older revision</td>
<td colspan='2' style="background-color: white; color:black; text-align: center;">Revision as of 08:40, 6 May 2015</td>
</tr><tr><td colspan="2" class="diff-lineno" id="mw-diff-left-l1" >Line 1:</td>
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<tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="color:black; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">==Introduction==</ins></div></td></tr>
<tr><td class='diff-marker'> </td><td style="background-color: #f9f9f9; color: #333333; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #e6e6e6; vertical-align: top; white-space: pre-wrap;"><div>This project aims to develop a medical device to assess chronic middle ear inflammation in children. For this we collaborate with ENT expert of the Nottingham Hearing Biomedical Research Unit.</div></td><td class='diff-marker'> </td><td style="background-color: #f9f9f9; color: #333333; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #e6e6e6; vertical-align: top; white-space: pre-wrap;"><div>This project aims to develop a medical device to assess chronic middle ear inflammation in children. For this we collaborate with ENT expert of the Nottingham Hearing Biomedical Research Unit.</div></td></tr>
<tr><td class='diff-marker'> </td><td style="background-color: #f9f9f9; color: #333333; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #e6e6e6; vertical-align: top; white-space: pre-wrap;"></td><td class='diff-marker'> </td><td style="background-color: #f9f9f9; color: #333333; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #e6e6e6; vertical-align: top; white-space: pre-wrap;"></td></tr>
<tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="color:black; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">==Medical Background and Motivation==</ins></div></td></tr>
<tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="color:black; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">Chronic Middle Ear Inflammation is characterized by inflammation of the middle ear mucosa (marked in red) and secretion of a liquid causing hearing loss. The only effective treatment is surgically draining the liquid and placing a ventilation tube through the eardrum. This is one of the most common surgeries in children in the developed world. In 25% of the cases the symptoms recur and there is no way of predicting the recurrence. It is hypothesised that a recurrence is linked to a persistent inflammation after surgery.</ins></div></td></tr>
<tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="color:black; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">{|align="center"</ins></div></td></tr>
<tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="color:black; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">|[[File:ear.png|200px|Caption Cartoon of the human ear. The red area shows the potentially inflamed mucosa.]]</ins></div></td></tr>
<tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="color:black; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">|}</ins></div></td></tr>
<tr><td class='diff-marker'> </td><td style="background-color: #f9f9f9; color: #333333; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #e6e6e6; vertical-align: top; white-space: pre-wrap;"></td><td class='diff-marker'> </td><td style="background-color: #f9f9f9; color: #333333; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #e6e6e6; vertical-align: top; white-space: pre-wrap;"></td></tr>
<tr><td class='diff-marker'>−</td><td style="color:black; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div><del class="diffchange diffchange-inline">Chronic </del>middle ear <del class="diffchange diffchange-inline">inflammation (Otits Media with Effusion) </del>is <del class="diffchange diffchange-inline">a very common state </del>in <del class="diffchange diffchange-inline">children </del>and <del class="diffchange diffchange-inline">can cause hearing loss persisting up </del>to <del class="diffchange diffchange-inline">several months</del>. The <del class="diffchange diffchange-inline">diagnosis, understanding </del>and <del class="diffchange diffchange-inline">follow up after surgery are neither ideal nor complete</del>. <del class="diffchange diffchange-inline">Thus</del>, <del class="diffchange diffchange-inline">we aim </del>to <del class="diffchange diffchange-inline">develop a diagnostic device </del>to assess the middle ear inflammation to <del class="diffchange diffchange-inline">improve </del>the <del class="diffchange diffchange-inline">understanding </del>and <del class="diffchange diffchange-inline">diagnosis</del>. This <del class="diffchange diffchange-inline">device </del>will <del class="diffchange diffchange-inline">combine spectroscopic measurements </del>and <del class="diffchange diffchange-inline">3D imaging to enable measurements within </del>the <del class="diffchange diffchange-inline">complex structured </del>middle ear. <del class="diffchange diffchange-inline">Once </del>the <del class="diffchange diffchange-inline">device </del>is <del class="diffchange diffchange-inline">designed, long term studies </del>are <del class="diffchange diffchange-inline">necessary </del>to proof <del class="diffchange diffchange-inline">its functionality and finally </del>to <del class="diffchange diffchange-inline">improve </del>the <del class="diffchange diffchange-inline">understanding of otits media with effusion</del>.</div></td><td class='diff-marker'>+</td><td style="color:black; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins class="diffchange diffchange-inline">This project aims to develop a medical device that will be able to determine whether the </ins>middle ear <ins class="diffchange diffchange-inline">mucosa </ins>is <ins class="diffchange diffchange-inline">still inflamed or has returned to normal </ins>in <ins class="diffchange diffchange-inline">order to improve diagnosis. Direct view of the mucosa is obscured by the eardrum. Consequently, an optical method must be implemented to allow measurements through the eardrum by maximising the signal detected from the mucosa </ins>and <ins class="diffchange diffchange-inline">minimising background reflections from the eardrum. The ratio of the detected signal at two wavelengths will allow assessment of the inflammation similar </ins>to <ins class="diffchange diffchange-inline">haemoglobin concentration measurements</ins>. The <ins class="diffchange diffchange-inline">use of confocal </ins>and <ins class="diffchange diffchange-inline">anti-confocal systems is investigated here</ins>.</div></td></tr>
<tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="color:black; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div> </div></td></tr>
<tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="color:black; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins class="diffchange diffchange-inline">==The Optical System==</ins></div></td></tr>
<tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="color:black; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins class="diffchange diffchange-inline">The optical system aims to solve two problems</ins>, <ins class="diffchange diffchange-inline">first </ins>to <ins class="diffchange diffchange-inline">maximise signal from the mucosa while minimising reflections from the eardrum, and second </ins>to <ins class="diffchange diffchange-inline">spectroscopically </ins>assess the middle ear <ins class="diffchange diffchange-inline">mucosa to determine the state of the </ins>inflammation<ins class="diffchange diffchange-inline">.</ins></div></td></tr>
<tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="color:black; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins class="diffchange diffchange-inline">===Spatial Filtering===</ins></div></td></tr>
<tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="color:black; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins class="diffchange diffchange-inline">Instead of using a confocal system to reject reflected light from the eardrum and select signal from the mucosa an anti-confocal system is introduced. In the anti-confocal system the pinhole is replaced by a stop rejecting light inside rather than outside its radius. This allows </ins>to <ins class="diffchange diffchange-inline">reject reflection from one plane - </ins>the <ins class="diffchange diffchange-inline">eardrum in this case - </ins>and <ins class="diffchange diffchange-inline">detect all other light</ins>. This <ins class="diffchange diffchange-inline">allows a higher signal to be detected and a bigger volume of the mucosa to be sampled.</ins></div></td></tr>
<tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="color:black; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins class="diffchange diffchange-inline">{|align="center"</ins></div></td></tr>
<tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="color:black; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins class="diffchange diffchange-inline">|[[File:confocal.png|400px]]</ins></div></td></tr>
<tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="color:black; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins class="diffchange diffchange-inline">|}</ins></div></td></tr>
<tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="color:black; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins class="diffchange diffchange-inline">{|align="center"</ins></div></td></tr>
<tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="color:black; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins class="diffchange diffchange-inline">|[[File:anti-confocal.png|400px]]</ins></div></td></tr>
<tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="color:black; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins class="diffchange diffchange-inline">|}</ins></div></td></tr>
<tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="color:black; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins class="diffchange diffchange-inline">===Spectroscopic System===</ins></div></td></tr>
<tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="color:black; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins class="diffchange diffchange-inline">The spectroscopic system will make use of the wavelength dependent absorption of haemoglobin in order to measure the blood concentration in the mucosa indicating the metabolism and state of the inflammation. Measurements </ins>will <ins class="diffchange diffchange-inline">be conducted at at least two wavelengths in the visible </ins>and <ins class="diffchange diffchange-inline">near infra-red range.</ins></div></td></tr>
<tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="color:black; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div> </div></td></tr>
<tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="color:black; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins class="diffchange diffchange-inline">==Progress==</ins></div></td></tr>
<tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="color:black; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins class="diffchange diffchange-inline">===Simulations===</ins></div></td></tr>
<tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="color:black; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins class="diffchange diffchange-inline">Imaging of </ins>the middle ear <ins class="diffchange diffchange-inline">using the anti-confocal system has been simulated using Monte-Carlo methods and compared to a conventional confocal system</ins>. <ins class="diffchange diffchange-inline">The simulation shows an improved performance of </ins>the <ins class="diffchange diffchange-inline">anti-confocal system considering signal strength and signal-to-background ratio.</ins></div></td></tr>
<tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="color:black; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins class="diffchange diffchange-inline">===Tissue Phantoms===</ins></div></td></tr>
<tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="color:black; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins class="diffchange diffchange-inline">Animal eardrums have been characterised and investigated in order to find tissue models for the human eardrum. Further, epoxy resin based tissue phantoms have been produced to model healthy and inflamed mucosa.</ins></div></td></tr>
<tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="color:black; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins class="diffchange diffchange-inline">===Optical System===</ins></div></td></tr>
<tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="color:black; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins class="diffchange diffchange-inline">The optical system is set up as bench top system. A CCD sensor </ins>is <ins class="diffchange diffchange-inline">used as confocal detector to allow easy variations of the filtering element of the (anti)-confocal system in software during post processing of the measurements.</ins></div></td></tr>
<tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="color:black; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins class="diffchange diffchange-inline">==Future Work==</ins></div></td></tr>
<tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="color:black; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins class="diffchange diffchange-inline">Next steps </ins>are to <ins class="diffchange diffchange-inline">experimentally characterise the optical system and </ins>proof <ins class="diffchange diffchange-inline">the concept using the tissue simulating phantoms. When shown </ins>to <ins class="diffchange diffchange-inline">be working </ins>the <ins class="diffchange diffchange-inline">system can be minimised and adopted for clinical use and tested on human subjects</ins>.</div></td></tr>
</table>
David Jung
https://optics.eee.nottingham.ac.uk/w/index.php?title=Endoscopic,_Spectroscopic_Imaging_of_the_Middle_Ear&diff=2027&oldid=prev
David Jung: Created page with "This project aims to develop a medical device to assess chronic middle ear inflammation in children. For this we collaborate with ENT expert of the Nottingham Hearing Biomedical ..."
2015-02-26T16:33:22Z
<p>Created page with "This project aims to develop a medical device to assess chronic middle ear inflammation in children. For this we collaborate with ENT expert of the Nottingham Hearing Biomedical ..."</p>
<p><b>New page</b></p><div>This project aims to develop a medical device to assess chronic middle ear inflammation in children. For this we collaborate with ENT expert of the Nottingham Hearing Biomedical Research Unit.<br />
<br />
<br />
Chronic middle ear inflammation (Otits Media with Effusion) is a very common state in children and can cause hearing loss persisting up to several months. The diagnosis, understanding and follow up after surgery are neither ideal nor complete. Thus, we aim to develop a diagnostic device to assess the middle ear inflammation to improve the understanding and diagnosis. This device will combine spectroscopic measurements and 3D imaging to enable measurements within the complex structured middle ear. Once the device is designed, long term studies are necessary to proof its functionality and finally to improve the understanding of otits media with effusion.</div>
David Jung