Plasmonic Detection of Bioelectrical signals

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This project investigates the utilisation of surface plasmon resonance as a voltage sensor for measuring the fast and small-amplitude electrical activity of the electrogentic cells. Electrical signals are used by these cells to communicate with each others, creating a coherent higher level function. For instance, information processing in the nervous system is mediated by electrical signals. Also, the function of the different types of muscle cells is controlled by electrical excitation. Accurate and reliable measurements of these signals at the cell level provides valuable in-vitro models for physiological and pharmacological investigations. Unlike the popular fluorescent and micro-electrode techniques, surface plasmon resonance is a label-free, non-invasive way to measure localized signals at the cell-substrate interface. Electrochemical methods are combined with sensitive surface plasmon resonance sensing platform to measure voltage between the metal surface and an artificial extracellular solution.